The devices analyse whole blood, serum, plasma, or a combination of these, and require very small sample volumes. The table in Appendix 1 provides an overview of the ten creatinine POC devices identified.Ĭreatinine POC devices allow rapid measurement of creatinine levels. Depending on significance of result, this may or may not be communicated to the patient by letter, telephone or in person.īenefits of POC creatinine testing: Rapid knowledge of renal function, facilitating referral of patients to secondary care (emergency department or clinic) if necessary. Results subsequently sent back to general practice typically within 24 hours. Speed and ease of testing may allow more frequent monitoring, and earlier detection and thus management of deteriorating renal function (2).ĭ) Detection of acute on chronic renal failure and acute kidney injury (AKI)Įxisting Technology: Blood samples sent from GP for analysis in local hospital laboratory. This might be particularly useful in patients with end stage renal failure requiring renal replacement therapy. Depending on significance of result, this may or may not be communicated to the patient by letter, telephone or in person.īenefits of creatinine POC testing: Rapid (within minutes) result of creatinine level allowing immediate feedback of result to patient.ī) Dose adjustment of prescribed medications in patients with renal impairment:Įxisting Technology: Typically, the most recent recorded renal function test is used to assist medication dose adjustment.īenefits of creatinine POC testing: Up-to-date renal function allowing immediate dose reduction of medications which require dose adjustment due to renal impairment if necessary (1).Įxisting Technology: Patients attend GP or hospital for blood tests to monitor renal function.īenefits of creatinine POC testing: Home testing would allow monitoring of renal function in comfort of own home. Results subsequently sent back to GP typically within 24 hours. Peritoneal effluent analysis is useful for rapid evaluation of membrane function.Current Practice and Advantages over Existing Technology:Ī) Screening for CKD by detection of elevated creatinine levels:Įxisting Technology: Blood samples sent from General Practice (GP) for analysis in local hospital laboratory. Hemodialysate analysis using i-STAT can be most valuable for rapidly checking dialysis machine function such as dialysate mixing and conductivity and ramping results and dialysate concentrations prepared in the unit. i-STAT blood analysis is most valuable when results are desired immediately, anywhere, including before, during and after dialysis in hemodialysis units. The results are viewed digitally on the analyzer and automatically on a small attachable printer. The i-STAT analyzer is simple to use, and dialysis nurses produced accurate results with 20 min training. We now report similar results for hemodialysis dialysate and peritoneal dialysis effluent. We have previously confirmed or demonstrated that accuracy and precision for blood assays are comparable to accepted laboratory methods. Eight different cartridges assay one to eight tests. The i-STAT hand-held analyzer assays ten tests including electrolytes, gases, urea, glucose, ionized calcium, and hematocrit.
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